Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation
نویسندگان
چکیده
منابع مشابه
Inherited disorders of straight chain fatty acid oxidation.
The first inherited disorder of organic acid metabolism was described in 1966, but it is only with the improvement in laboratory facilities in recent years that the true incidence of these disorders is beginning to be appreciated. Defects in the mitochondrial oxidation of straight chain fatty acids seem to be particularly common (as inborn errors of metabolism go) even though the first example,...
متن کاملOn rate-controlling factors of long chain fatty acid oxidation.
Under appropriate conditions, mitochondria from red and white skeletal muscle of rabbit and from heart and liver of rat respired as rapidly with palmitoyl-coenzyme A plus carnitine as with palmitoyl carnitine. The ability of heart and skeletal muscle mitochondria to oxidize palmitoyl groups is limited by the acetyl-CoA-producing capacity of the 0 oxidation cycle rather than through a limitation...
متن کاملClofibrate increases long-chain fatty acid oxidation by neonatal pigs.
BACKGROUND Utilization of energy-dense lipid fuels is critical to the rapid development and growth of neonates. OBJECTIVE To increase efficiency of milk fat utilization by newborn pigs, the effect of clofibrate on in vivo and in vitro long-chain fatty acid (LCFA) oxidation was evaluated. METHODS Newborn male pigs were administered 5 mL of vehicle (2% Tween 80) with or without clofibrate (75...
متن کاملRegulation of plasma long-chain fatty acid oxidation in relation to uptake in human skeletal muscle during exercise.
In the present study, we investigated possible sites of regulation of long-chain fatty acid (LCFA) oxidation in contracting human skeletal muscle. Leg plasma LCFA kinetics were determined in eight healthy men during bicycling (60 min, 65% peak oxygen uptake) with either high (H-FOX) or low (L-FOX) leg fat oxidation (H-FOX: 1,098 +/- 140; L-FOX: 494 +/- 84 micromol FA/min, P < 0.001), which was ...
متن کاملCombined Effects of Phytochemicals and Exercise on Fatty Acid Oxidation
Purpose The purpose of this review is to discuss current views regarding the acute effects of phytochemicals, exercise, and exercise plus phytochemicals on fatty acid oxidation. Methods Data acquired from human and animal studies were comprehensively assessed to determine the single and combined effects of phytochemicals and exercise on fatty acid oxidation. In addition, underlying mechanisms...
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ژورنال
عنوان ژورنال: Molecular Genetics and Metabolism
سال: 2012
ISSN: 1096-7192
DOI: 10.1016/j.ymgme.2011.09.030